For Pike and Musky fishing it is pretty simple...
If you are live lining with a float/bobber and you see the float go under you should immediately set the hook as the pike/musky has already ambushed/inhaled the bait.. they do not partially pick up the bait and run.. they inhale it.... float goes under then set hook immediately...
If you are live lining off the bottom (and are specifically going for pike/musky) and you see the line start to move then set the hook... do not wait as the pike/musky will have already started to swallow and you dont want that to happen..
Fishing any kind of moving artificial for pike/musky they will more or less hook themselves... I have never ever had to set a hook when retrieving spinner, spoons, top water, etc.... they will attack and all you will feel is your line come to a complete stop and most of the time you will think you are snagged for a quick second.. Basically you will be retreiving and then the line will just suddenly stop dead and then you will start to feel the pull and wieght of the fish... Pike/Musky more or less feel like dead wieght pulling on the end of your line... they will not run like a smallmouth because they pretty much bog down and pull until you start to reel and manuever them in..
Good luck
